Publications and Manuscripts

  1. Chorba JS. Aligning public and institutional incentives to advance biomedical research. Nat Cardiovasc Res. 2024 Jan 17;3:1-2. doi: 10.1038/s44161-023-00407-7
  2. Boctor D, Bakke B, Chorba JS. The Silent Threat: Bartonella quintana endocarditis unveiling heart failure and severe pulmonary hypertension. Am J Case Rep. 2023 Dec 11;24:e942160. doi: 10.12659/AJCR.942160
  3. Prince J, Maidens J, Kieu S, Currie C, Barbosa D, Hitchcock C, Saltman A, Norozi K, Wiesner P, Slamon N, Del Grippo E, Padmanabhan D, Subramanian A, Manjunath C, Chorba JS*, Venkatraman S*. Deep learning algorithms to detect murmurs associated with structural heart disease. J Am Heart Assoc. 2023 Oct 17;12(20):e030377. doi: 10.1161/JAHA.123.030377 (Shared senior authorship)
  4. Xia VQ, Ong C-M, Zier LS, MacGregor JS, Wu AHB, Chorba JS. Heparin does not regulate circulating human PCSK9 in a general population. Arterioscler Thromb Vasc Biol. 2023 Feb;43(2):352-8. doi: 10.1161/ATVBAHA.122.318556  (Corresponding author)
  5. Chorba JS, Xia VQ, Smith GA, Padmanabhan A. Rapid multiplexed flow cytometric validation of CRISPRi sgRNAs in tissue culture. Bio Protoc. 2023 Jan 20;13(2):e4591. doi: 10.21769/BioProtoc.4591 (Corresponding author)
  6. Smith GA*, Padmanabhan A*, Lau BH, Pampana A, Li L, Lee YC, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Sci Transl Med. 2022 Sept 14;14(662);eabj8670. doi: 10.1126/scitranslmed.abj8670 (Corresponding author, Research Highlight in Nat Rev Cardiol, doi: 10.1038/s41569-022-00795-6)
  7. Maidens, J, Chorba JS, Thomas JD. Physical maneuvers and recent tools to break the silence of clinically undetectable heart sounds. JAMA Intern Med. 2022 May 1;182(5):574-5. doi: 10.1001/jamainternmed.2022.0399
  8. Chorba JS*, Shapiro AM*, Le L, Maidens J, Prince J, Pham S, Kanzawa MM, Barbosa DN, Currie C, Brooks C, White BE, Huskin A, Paek J, Geocaris J, Elnathan D, Ronquillo R, Kim R, Alam ZH, Mahadevan VS, Fuller SG, Stalker GW, Bravo SA, Jean D, Lee JJ, Gjergjindreaj M, Mihos CG, Forman ST, Venkatraman S, McCarthy PM, Thomas JD. Deep learning algorithm for automated cardiac murmur detection via a digital stethoscope platform. J Am Heart Assoc. 2021 May 4;10(9):e019905. doi: 10.1161/JAHA.120.019905 (Shared first and corresponding authorship, Research Highlight in Nat Rev Cardiol, doi: 10.1038/s41569-021-00567-8)
  9. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O’Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Kain AM, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang X-P, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O’Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang H-Y, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d’Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garcia-Sastre A, Shokat K, Shoichet BK, Krogan NJ. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 Jul;583(7816):459-468. doi:10.1038/s41586-020-2286-9.
  10. Galvan AM, Chorba JS. Cell-associated, heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake. J Lipid Res. 2019 Jan;60(1):71-84. doi:10.1194/jlr.M087189 (Corresponding author, Highlighted in ASBMB Today)
  11. Chorba JS, Galvan AM, Shokat KM. A high-throughput luciferase assay to evaluate proteolysis of the single-turnover protease PCSK9. J Vis Exp. 2018 Aug 28;(138):e58265. doi:10.3791/58265 (Corresponding author)
  12. Chorba JS, Galvan AM, Shokat KM. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018 Feb 9;293(6):1875-86. doi:10.1074/jbc.RA117.000754 (Corresponding author; Article featured on cover)
  13. Wertheim BM, Aguirre AJ, Bhattacharyya RP, Chorba J, Jadhav AP, Kerry VB, Macklin EA, Motyckova G, Raju S, Lewandrowski K, Hunt DP, Wright DE. An educational and administrative intervention to promote rational laboratory test ordering on an academic general medical service. Am J Med. 2016 Sept 9;S0002-9343(16):30908-1. doi:10.1016/j.amjmed.2016.08.021
  14. Chorba JS, Shokat KM. The PCSK9 active site and cleavage sequence differentially regulate protein secretion from proteolysis. J Biol Chem. 2014 Oct 14;289(42):29030-42. doi:10.1074/jbc.M114.59861. (Corresponding author)
  15. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb;43(2):441-5. doi:10.1161/STROKEAHA.111.629212. 
  16. Dewland TA, Chorba JS, Goldschlager N, Marcus GM. Sustained ventricular fibrillation in a conscious patient. Arch Intern Med. 2011 Jun 13;171(11):973, 974-5. doi:10.1001/archinternmed.2011.235.
  17. Li J*, Chorba JS*, Whelan SP. Vesicular stomatitis viruses resistant to methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation. J Virol. 2007 Apr;81(8):4104-15. doi:10.1128/JVI.02681-06. (Shared first authorship)
  18. Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ. Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett. 2003 Feb 10;13(3):547-51. doi:10.1016/s0960-894x(02)00945-9.
  19. Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh DL, Iwanowicz EJ. Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series. Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6. doi:10.1016/s0960-894x(02)00944-7.

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